VIP (Vasoactive Intestinal Peptide) (5mg)

Description Vasoactive Intestinal Peptide (VIP) is a synthetic 28-amino acid peptide identical to the endogenous human neuropeptide. VIP is widely employed to investigate G-protein coupled receptor (GPCR) signaling through the VPAC1 and VPAC2 receptors. Experimental workflows utilize VIP to explore its pleiotropic regulatory roles, ranging from the modulation of pro-inflammatory cytokine secretion and T-cell differentiation to the regulation of vascular smooth muscle tone and barrier function in gastrointestinal models. It serves as a critical reference standard in assays quantifying neuroendocrine-immune interactions. Biochemical Characteristics Chemically, VIP is a linear polypeptide belonging to the secretin/glucagon superfamily, characterized by a diffuse hydrophobic face that facilitates interaction with the N-terminal ectodomain of Class B GPCRs. Sequence/Structure: A 28-residue peptide (His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2). Permeability: Interacts with cell surface VPAC1 and VPAC2 receptors; research often utilizes specific delivery systems (e.g., micelles) to study intracellular downstream effects due to rapid enzymatic degradation in free form. Specificity: Highly specific agonist for VPAC1 and VPAC2 receptors, and with lower affinity for the PAC1 receptor. Chemical Properties Property Specification Molecule Name Vasoactive Intestinal Peptide (VIP) Synonyms VIP; Vasoactive Intestinal Polypeptide Molecular Formula C147H238N44O42S Molecular Weight 3326.8 g/mol Form Lyophilized Powder Purity ≥99% (Verified via HPLC) Solubility Soluble in water and aqueous buffers Documentation COA available per lot; SDS available